Research, Resources, Expertise & Funding
Sanger Research groups
Experimental Cancer Genetics
The Adams Group aims to understand the biological role of genes influencing cancer development.
Translational Cancer Genomics
We investigate how abnormalities in the DNA of cells contribute to cancer and impact on patient responses to therapy. This provides fundamental insights into disease mechanisms with implications for the development of improved therapies.
Cancer Functional Genomics
Our work is in the understanding of how cancer genomes affect drug sensitivity and resistance. Ultimately our goal is to create knowledge of what drives drug response and resistance in cancer that will be of benefit to patients.
Stem Cell Genetics
The Yusa laboratory focuses on the development of genome engineering technologies that allow us to perform unbiased genome-wide genetic screens in mammalian cells. We have recently adopted the CRISPR-Cas9 technology as a screening tool and generated genome-scale lentiviral CRISPR libraries.
Genetic Screens of Cellular Traits
We develop probabilistic models and software tools to accurately analyse the readouts of CRISPR/Cas9 based genetic screens.
The Cancer Dependency Map
The DepMap at Sanger is part of the larger Cancer Dependency Map effort, in collaboration with the Broad Institute.
COSMIC, the Catalogue Of Somatic Mutations In Cancer, is the world's largest and most comprehensive resource for exploring the impact of somatic mutations in human cancer.
WTSI Genome Editing
WTSI Genome Editing (WGE) is a website that provides tools to aid with genome editing of human and mouse genomes
Open Targets Platform
Comprehensive and robust data integration for access to and visualisation of potential drug targets associated with disease.
Human Cancer Model Initiative
An international consortium generating novel human tumor-derived culture models, which are annotated with genomic and clinical data.
CTD²: Cancer Target Discovery And Development
Bridges the gap between the enormous volumes of data generated by genomic characterization studies and the ability to use these data for the development of human cancer therapeutics.
Provides visualization, analysis and download of large-scale cancer genomics data sets.