Model Relationships

The Cell Model Passports connects cell models originating from the same patient or sample and identifies the parental cell model of sub-clones or derivatives.

Where multiple models have been derived from a single patient the Cell Model Passports aims to provide details on how the samples are related, enabling researchers to make informed decisions regarding their use.

An example Patient, Sample, Model relationship is illustrated in the figure below:

Model relationships are constructed by combining information obtained during annotation with data obtained from model identification resources such as International Cell Line Authentication Committee (ICLAC) and additional publications. In addition STR profiles obtained during model curation or internally at the Sanger Institute are compared to inform model-patient associations. The Cell Model Passports conservatively assigns models sharing common ancestry to separate samples from the same patient unless evidence indicates otherwise.