Genomics of Drug Sensitivity in Cancer

The Genomics of Drug Sensitivity in Cancer (GDSC) project aims to identify the molecular features of cancers that predict response to anti-cancer drugs. The GDSC web portal enables exploration and anlysis of this data focusing on identifying molecular biomarkers of drug sensitivity based on queries of specific anticancer drugs or cancer genes. Graphical representations of the data are used throughout with links to related resources and all datasets are fully downloadable. GDSC provides a unique resource incorporating large drug sensitivity and genomic datasets to facilitate the discovery of new therapeutic biomarkers for cancer therapies.

Publication: Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Res, 2013.

Screening Methods & Data Processing

Drug sensitivity data is currently only available for download from the GDSC site and is not available through the DepMap API.

The Cell Model Passports provides users with highlights from the GDSC, listing the five drugs with the lowest relative sensitivity (IC50 Z-score), for each model with available data.

GDSC: Documentation Pages